MigraDoc is a document generator. It supports almost anything you find in any good word processor. You just add paragraphs, tables, charts, arrange all this in sections, use bookmarks to create links, tables of contents, indexes, etc. MigraDoc will do the layout creating page breaks as needed. MigraDoc will create PDF or RTF documents.

PDFsharp is a .NET library for processing PDF file. You create PDF pages using drawing routines known from GDI+. Almost anything that can be done with GDI+ will also work with PDFsharp. Only basic text layout is supported by PDFsharp, and page breaks are not created automatically. The same drawing routines can be used for screen, PDF, or meta files.

Use PDFsharp or MigraDoc?
Use PDFsharp if you want to create PDF files only, but be able to control every pixel and every line that is drawn.
Use MigraDoc if you need documents as PDF and RTF files and if you want to enjoy the comfort of a word processor.

Mixing PDFsharp and MigraDoc
If MigraDoc does almost anything you need, then you can use MigraDoc to create PDF files and post-process them with PDFsharp to add some extra features.
Soon you'll be able to use placeholders in MigraDoc and later on use PDFsharp to draw these placeholders.

Or use PDFsharp to create the document but use MigraDoc to create individual pages. This could be the best choice if your application uses lots of graphics, but also needs some layouted text.

Information about PDFsharp’s features
Key Features
Creates PDF documents on the fly from any .NET language
Easy to understand object model to compose documents
One source code for drawing on a PDF page as well as in a window or on the printer
Modify, merge, and split existing PDF files
Images with transparency (color mask, monochrome mask, alpha mask)
Newly designed from scratch and written entirely in C#
The graphical classes go well with .NET

PDFsharp Downloads at sourceforge.net

PDFsharp project at sourceforge.net