We've just released a patch for Delphi 10.3.3, addressing the following issues when debugging Android 64-bit applications on Android devices:

RSP-26704 Debugging 64 bit Android application hangs the IDE
RSP-26824 Breakpoints do not work in Android 64 project
RSP-26774 Unable to start GDB kernel after switching from debugging 32 to 64 Android
plus a number of internally reported issues including issues in the following areas:
evaluating expressions or variables
connecting to an Android device
slowdown of a debugged app when the debugger is attached
handling very large source files
switching threads from the Threads view
displaying memory in the CPU view
and others.